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01 Mar 2019. Due to a large number of tissue requests, currently BPTB are unable to accept applications requesting prospective fresh tissue collection. This will be applicable for the next 3 months. In 3 months' time we will assess the situation and update accordingly.

Information for Researchers

What are biomarkers?

Biological markers which can be detected in human body though a range of tests can enable doctors to do various things for a disease. They can be divided as:
  • Diagnostic biomarkers: enable early diagnosis
  • Prognostic biomarkers: define patients' requirements for additional treatment
  • Predictive biomarkers: Define the type of treatment
    • Pharmacodynamics: how patient may respond to treatment for e.g., how a drug/medicine may be distributed in body and what effect/side-effect it may have
    • Efficacy response: whether patients are responding to treatment

So what is missing?

  • To develop a diagnostic test, we are unable to access samples that are
    • uniformly collected
    • reliably stored
    • clinically annotated
  • These patients are often seen by diverse specialities in clinics at different sites
  • No clear collaboration between clinicians working in different specialities and scientists with distinct expertise.

What are the merging opportunities in research and treatment of cancer patients?

  • More effective treatments
  • Centralisation of services leads to highly experienced teams with efficient protocols
  • Cutting edge technologies in research such as
    • Next generation sequencing
    • Proteomics, metabolomics, and other -omics platforms
    • Cell and molecular biology
    • Targeted treatment regimens
    • Bioinformatics and IT
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